Hiroyasu Esumi Selected Research

pyrvinium (Vankin)

8/2012	An anticancer agent, pyrvinium pamoate inhibits the NADH-fumarate reductase system--a unique mitochondrial energy metabolism in tumour microenvironments.
7/2010	The NADH-fumarate reductase system, a novel mitochondrial energy metabolism, is a new target for anticancer therapy in tumor microenvironments.
8/2004	Antitumor activity of pyrvinium pamoate, 6-(dimethylamino)-2-[2-(2,5-dimethyl-1-phenyl-1H-pyrrol-3-yl)ethenyl]-1-methyl-quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation.

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Hiroyasu Esumi Research Topics

Disease

56	Neoplasms (Cancer) 12/2019 - 02/2002
22	Pancreatic Neoplasms (Pancreatic Cancer) 01/2018 - 09/2002
16	Starvation 01/2016 - 01/2002
15	Hypoxia (Hypoxemia) 10/2014 - 01/2002
9	Colorectal Neoplasms (Colorectal Cancer) 01/2018 - 03/2004
6	Stomach Neoplasms (Stomach Cancer) 01/2017 - 09/2003
5	Carcinogenesis 02/2014 - 10/2002
4	Lung Neoplasms (Lung Cancer) 12/2019 - 04/2006
3	Ischemia 01/2019 - 01/2002
3	Adenocarcinoma of Lung 07/2015 - 07/2014
3	Melanoma (Melanoma, Malignant) 12/2011 - 01/2003
3	Colonic Neoplasms (Colon Cancer) 02/2011 - 02/2002
3	Skeletal Abnormalities Mandibular Hypoplasia Auditory Canal Atresia Short Stature 01/2006 - 01/2003
3	Hepatocellular Carcinoma (Hepatoma) 09/2005 - 09/2003
2	Prostatic Neoplasms (Prostate Cancer) 04/2013 - 12/2011
2	Necrosis 08/2009 - 01/2008
2	Inflammation (Inflammations) 02/2009 - 01/2003
2	T-Cell Lymphoma (Lymphoma, T Cell) 11/2007 - 01/2006
2	Multiple Myeloma 11/2007 - 10/2005
2	Lymphoma (Lymphomas) 01/2006 - 02/2002
2	Ataxia Telangiectasia (Louis Bar Syndrome) 11/2004 - 01/2003
1	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 01/2018
1	Hyperglycemia 12/2016

Drug/Important Bio-Agent (IBA)

17	Glucose (Dextrose)FDA LinkGeneric 01/2019 - 01/2002
15	Phosphotransferases (Kinase)IBA 01/2019 - 01/2003
11	Proteins (Proteins, Gene)FDA Link 10/2014 - 08/2002
9	EnzymesIBA 01/2017 - 10/2004
8	Pharmaceutical PreparationsIBA 12/2019 - 02/2006
8	Oxygen (Dioxygen)IBA 08/2015 - 09/2002
8	Messenger RNA (mRNA)IBA 10/2014 - 11/2002
8	AMP-Activated Protein KinasesIBA 01/2006 - 01/2002
6	DNA (Deoxyribonucleic Acid)IBA 10/2019 - 02/2002
6	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2014 - 08/2002
6	Amino Acids FDA Link 04/2013 - 09/2002
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2005 - 08/2002
5	arctigeninIBA 01/2018 - 02/2006
5	Antineoplastic Agents (Antineoplastics)IBA 01/2016 - 06/2004
5	FructoseIBA 10/2014 - 10/2004
4	Biomarkers (Surrogate Marker)IBA 10/2019 - 01/2014
4	Lactic Acid (Lactate)FDA LinkGeneric 01/2018 - 06/2009
4	IsoenzymesIBA 10/2014 - 01/2005
4	oxalylglycineIBA 01/2006 - 10/2004
4	Mixed Function Oxygenases (Monooxygenases)IBA 01/2006 - 10/2004
3	Aldehyde DehydrogenaseIBA 01/2017 - 10/2002
3	ErbB Receptors (EGF Receptor)IBA 07/2015 - 01/2011
3	Biological ProductsIBA 12/2014 - 04/2003
3	pyrvinium (Vankin)FDA Link 08/2012 - 08/2004
3	Propolis (Bee Bread)IBA 04/2010 - 01/2008
3	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 02/2009 - 04/2003
3	CarcinogensIBA 02/2009 - 10/2002
2	Monoclonal AntibodiesIBA 10/2019 - 11/2017
2	Phosphatidylinositol 3-Kinase (1 Phosphatidylinositol 3 Kinase)IBA 01/2018 - 07/2015
2	Gemcitabine FDA Link 01/2018 - 12/2016
2	AntibodiesIBA 11/2017 - 01/2011
2	Methanol (Carbinol)IBA 01/2017 - 01/2016
2	PhytochemicalsIBA 01/2017 - 09/2009
2	AnthelminticsIBA 08/2012 - 07/2010
2	fumarate reductase (NADH)IBA 08/2012 - 07/2010
2	Electron Transport Complex II (Succinate-Coenzyme Q Reductase)IBA 08/2012 - 07/2010
2	Hypoglycemic Agents (Hypoglycemics)IBA 08/2012 - 05/2011
2	angelmarinIBA 05/2012 - 02/2006
2	Succinate Dehydrogenase (Fumarate Reductase)IBA 05/2012 - 07/2010
2	Protein Isoforms (Isoforms)IBA 05/2012 - 12/2005
2	Formaldehyde (Formol)FDA Link 02/2011 - 01/2011
2	ParaffinIBA 02/2011 - 01/2011
2	Ethanol (Ethyl Alcohol)IBA 09/2009 - 10/2002
2	NucleotidesIBA 06/2009 - 11/2002
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 05/2008 - 09/2005
2	Cyclin D2IBA 11/2007 - 01/2006
2	AcetaldehydeIBA 07/2007 - 10/2002
2	Insulin-Like Growth Factor I (IGF-1)IBA 05/2006 - 11/2004
2	kigamicin DIBA 04/2006 - 06/2004
2	Protein Kinases (Protein Kinase)IBA 10/2005 - 09/2005
2	Deferoxamine (Desferal)FDA LinkGeneric 01/2005 - 10/2004
2	cobaltous chloride (cobalt(II)chloride)IBA 01/2005 - 10/2004
1	Nucleic AcidsIBA 10/2019
1	Sucrose (Saccharose)IBA 01/2019
1	Insulin (Novolin)FDA Link 01/2019
1	AntioxidantsIBA 01/2018
1	acetovanillone (apocynin)IBA 01/2018
1	Interleukin-8 (Interleukin 8)IBA 01/2018
1	NADPH Oxidases (NAD(P)H oxidase)IBA 01/2018
1	Therapeutic UsesIBA 11/2017
1	cyclohexeneIBA 01/2017
1	ChalconesIBA 01/2017
1	ThymidineIBA 01/2017
1	nicolaioidesin CIBA 01/2017
1	isopanduratin A1IBA 01/2017
1	Thymidine PhosphorylaseIBA 01/2017
1	gamma-Glutamyltransferase (gamma-Glutamyl Transpeptidase)IBA 12/2016
1	BilirubinIBA 12/2016
1	mangiferolate BIBA 01/2016
1	indoleIBA 01/2016
1	AcidsIBA 01/2016

Therapy/Procedure

4	Therapeutics 01/2014 - 06/2004
2	Radiotherapy 01/2018 - 05/2008
2	Drug Therapy (Chemotherapy) 01/2018 - 05/2012
2	Endoscopes 01/2014 - 09/2004
2	Lasers (Laser) 01/2014 - 12/2004
2	Oral Administration 04/2006 - 06/2004